THE FATE OF BIOGENIC MONOAMINES IN PERFUSED RABBIT LUNG
نویسندگان
چکیده
منابع مشابه
The fate of biogenic monoamines in perfused rabbit lung.
1. Inactivation of beta-phenylethylamine and several of its derivatives was studied in a preparation of rabbit lung perfused with Krebs physiological medium at 37 degrees C. Inactivation or removal of these compounds was calculated as the difference between the concentration of each amine in the perfusion medium and the effluent, collected separately from each lung. The extent of amine metaboli...
متن کاملBiogenic monoamines in preimplantation development.
BACKGROUND The involvement of biogenic monoamines in early ('preneural') embryogenesis has been well documented in lower vertebrates, but much less information is available about the role of these molecules in the earliest stages of development in mammals, including humans. METHODS Databases (PubMed, ISI Web of Knowledge and Scopus) were searched for studies relating to biogenic monoamines fu...
متن کاملThe Role of Anion Exchanger on Pulmonary Vascular Response to Sustained Alveolar Hypoxia in the Isolated Perfused Rabbit Lung
Background: Some respiratory diseases may induce alveolar hypoxia thereby hypoxic pulmonary vasoconstriction (HPV). However, the mechanisms of this physiologic phenomenon are not fully understood. This study was the first to investigate the role of anion exchanger in sustained HPV.Methods: Experiments were performed in the isolated perfused rabbit lung. After preparation, the lungs were divided...
متن کاملQuantitative evaluation of hemodynamic parameters during acute alveolar hypoxia and hypercapnia in the isolated ventilated-perfused rabbit lung
Introduction: Acute respiratory disorders such as obstructive pulmonary diseases and hypoventilation may lead to alveolar hypoxia and hypercapnia which their effects on pulmonary vascular beds are controversial. The aim of this study was to establish the isolated perfused lung setup and investigate the effects of alveolar hypoxia and hypercapnia on pulmonary vascular resistance. Methods: White ...
متن کاملIsolated perfused rabbit lung: a critical appraisal.
The isolated perfused lung (IPL), when compared to available in vitro and in vivo pulmonary systems, is a preparation that fulfills a majority of the ideal criteria for studying metabolism, binding and/or physiological response to xenobiotics. The IPL is an exceptionally useful method when there is a need for concurrent administration of multiple agents in different physical forms. Various deta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1977
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1977.tb07725.x